OB-1

• Description:

  OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin[1].

• UNSPSC:

  12352005

• Target:

  SPFH Protein Superfamily

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ob-1.html

• Purity:

  99.12

• Solubility:

  DMSO : 12.73 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(C1=C(C2=CC=CC=C2)OC3=CC=C(OC4=C([N+]([O-])=O)N=CN4C)C=C13)OCC

• Molecular Formula:

  C21H17N3O6

• Molecular Weight:

  407.38

• References & Citations:

  [1]Wetzel C, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat Neurosci. 2017 Feb;20 (2) :209-218.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Stomatin

• CAS Number:

  [300803-69-4]