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K-252d

CAT: 0804-HY-130748Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-130748Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM) . It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM) .
CAS Number
[105114-22-5]
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; PKC
Type
Natural Products
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/k-252d.html
Smiles
O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)N([C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)C7=C3C=CC=C7
Molecular Formula
C26H23N3O5
Molecular Weight
457.48
References & Citations
[1]Nakanishi, et al. K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39 (8), 1066-1071 (1986) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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