K-252b

CAT: 0804-HY-N6734Size: 500 µgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-N6734Size:500 µg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

K-252b, an indolocarbazole isolated from the actinomycete Nocardiopsis, is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely [1][2][3].

CAS Number

99570-78-2

UNSPSC

12352005

Target

PKC

Type

Natural Products

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/k-252b.html

Solubility

10 mM in DMSO

Smiles

C[C@@]([C@@]1(O)C(O)=O)(O[C@](N2C3=CC=CC=C43)([H])C1)N5C(C2=C4C6=C7CNC6=O)=C7C8=CC=CC=C58

Molecular Formula

C26H19N3O5

Molecular Weight

453.45

References & Citations

[1]Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39 (8), 1072-1078 (1986) .|[2]Plomp, J.J., et al. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of α-bungarotoxin-treated rats Journal of Physiology 493, 175-186 (1996) .|[3]Zhu, X., et al. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro Biochemistry Journal 323, 637-643 (1997) .

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-130748	K-252d
HY-N6732-01	K-252a
HY-N6736-01	K-252c
HY-N15509	Harzianol K
HY-15499	K-832
HY-N10290	Cytochalasin K
HY-N3338	Macrocarpal K
HY-N8668	Eudesmane K
HY-136943	K-41
HY-N10211	Saccharothrixin K

Alternative Products

Catalog	Name
MBS565506-01	K-252b
AM025C	MIRacleTM isc-miR-252b miRNA Agomir/Antagomir
RM-Z240000-01	S-Antcin K; Zhankuic acid K
GTR19066420-01	R-K-R-A-R-K-E
MBS1070614-01	Recombinant Escherichia coli Protein K (K)
8000124	Proteinase K (contains Proteinase K solution)
351334-01	KRAS (GTPase Kras, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, NS3, RASK2, GTPase Kras, K-RAS2A, K RAS2B, K RAS4A, K RAS4B, KI RAS, KRAS 1, NS 3)
P6803	PDuRCC-K
BIO-37039	Proteinase K
BA4372-1	K-756

K-252b

Related Products

Alternative Products

Popular Products