K-252c

CAT: 0804-HY-N6736-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6736-01Size:1 mg
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Description
K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].
CAS Number
[85753-43-1]
UNSPSC
12352005
Hazard Statement
H302-H319
Target
Apoptosis; Bacterial; Beta-lactamase; PKC
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/k-252c.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6
Molecular Formula
C20H13N3O
Molecular Weight
311.34
Precautions
P264-P270-P280-P305+P351+P338-P330-P501
References & Citations
[1]Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39 (22), 4471-4477 (1996) .|[2]Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30 (3), 270-274 (2007) .|[3]Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48 (1), 49-60 (2000) .|[4]McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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