PLAUR Antibody (Center) [APR06076G]

• Background:

  Tissue Location: Expressed in neurons of the rolandic area of the brain (at protein level) . Expressed in the brain

• Synonyms:

  Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR

• Gene Name:

  PLAUR

• Gene ID:

  5329

• UniProt:

  Q03405

• Chromosomal Location:

  Cell membrane. Cell projection, invadopodium membrane Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin- dependent manner. [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}

• Applications:

  IHC-P, WB

• Dilution:

  IHC-P--1:100~500 WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

• Molecular Weight:

  36978

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PLAUR Antibody (Center) [APR06076G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5329

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q03405