PLAUR (NM_001005376) Human Recombinant Protein

• Background:

  This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

• Synonyms:

  CD87; U-PAR; UPAR; URKR

• Gene ID:

  5329

• UniProt:

  Q03405

• Accession Number mRNA:

  NM_001005376

• Chromosomal Location:

  19q13.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Complement and coagulation cascades

• Field of Research:

  Complement and coagulation cascades

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  28.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PLAUR

• Species:

  Human

• Protein ID:

  NP_001005376

• Overview:

  Purified recombinant protein of Homo sapiens plasminogen activator, urokinase receptor (PLAUR), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5329

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q03405

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001005376

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001005376