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PLAUR Antibody

CAT: 0223-63-436Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-436Size:400 µL
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Background
The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion.1 It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.2 PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue.3 Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer.4 UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
NCBI Gene ID
5329
Swiss Prot
Q03405
Accession Number
Q03405
Host
Rabbit
Reactivity
Human
Immunogen
This PLAUR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-166 amino acids from the Central region of human PLAUR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Symbol
PLAUR
NCBI Official Name
Urokinase plasminogen activator surface receptor
NCBI Organism
Homo sapiens
Background Reference 01
Borgfeldt, C., et al., Int. J. Cancer 107 (4) :658-665 (2003) .
Background Reference 02
Tran, H., et al., Mol. Cell. Biol. 23 (20) :7177-7188 (2003) .
Background Reference 03
Coleman, J.L., et al., Infect. Immun. 71 (10) :5556-5564 (2003) .
Background Reference 04
Sturge, J., et al., J. Cell Biol. 162 (5) :789-794 (2003) .
Other Product Names
Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR
Tested Applications
WB, IHC-P
Protein ID
465003
Physical Properties
Liquid

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