TFLLR-NH2(TFA)

TFLLR-NH2(TFA)

• CAS Number: 1313730-19-6
• UNSPSC Description: TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.
• Target Antigen: Protease Activated Receptor (PAR)
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/TFLLR-NH2_TFA_.html
• Purity: 99.78
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O.FC(C(O)=O)(F)F
• Molecular Weight: 761.83
• References & Citations: [1]de Garavilla L, et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001 Aug;133(7):975-87.|[2]Kawabata A, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.|[3]Jia Y, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncol Rep. 2015 Jun;33(6):2681-8.bioRxiv. 2024 Jul 26:2024.07.26.605282.|Res Sq. 2024 Sep 04.|Cells. 2023 May 24, 12(11), 1461.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported