TFLLR-NH2

• UNSPSC Description:

  TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM.

• Target Antigen:

  Protease Activated Receptor (PAR)

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/TFLLR-NH2.html

• Solubility:

  10 mM in H2O

• Smiles:

  N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O

• Molecular Weight:

  647.81

• References & Citations:

  [1]de Garavilla L, et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001 Aug;133(7):975-87.|[2]Kawabata A, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.|[3]Jia Y, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncol Rep. 2015 Jun;33(6):2681-8.Cells. 2023 May 24, 12(11), 1461.|bioRxiv. 2024 Jul 26:2024.07.26.605282.|Res Sq. 2024 Sep 04.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  197794-83-5