TFLLR-NH2

• Description:

  TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM.

• UNSPSC:

  12352209

• Target:

  Protease Activated Receptor (PAR)

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/TFLLR-NH2.html

• Purity:

  99.04

• Solubility:

  10 mM in H2O

• Smiles:

  N=C (N) NCCC[C@@H] (C (N) =O) NC ([C@H] (CC (C) C) NC ([C@H] (CC (C) C) NC ([C@H] (CC1=CC=CC=C1) NC ([C@H] ([C@H] (O) C) N) =O) =O) =O) =O

• Molecular Formula:

  C31H53N9O6

• Molecular Weight:

  647.81

• References & Citations:

  [1]de Garavilla L, et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001 Aug;133 (7) :975-87.|[2]Kawabata A, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.|[3]Jia Y, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncol Rep. 2015 Jun;33 (6) :2681-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  PAR1

• Citation 01:

  Cells. 2023 May 24;12 (11) :1461.|bioRxiv. 2024 Jul 26:2024.07.26.605282.|Res Sq. 2024 Sep 04.

• CAS Number:

  197794-83-5