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Anti-CRP Purified

CAT: 0270-11-484-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-11-484-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein composed of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa) . CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
Certification
RUO
Reactivity
Human
Immunogen
Purified human CRP
Target Antigen
CRP
Clone
C7
Applications
ELISA
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Krämer PM, Kess M, Kremmer E, Schulte-Hostede S: Multi-parameter determination of TNFα , PCT and CRP for point-of-care testing. Analyst. 2011 Feb 21;136 (4) :692-5., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=kremmer+e+schulte-hostede+s
Other References
*van der Harst P, Voors AA, Volbeda M, Buikema H, van Veldhuisen DJ, van Gilst WH: Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting. Am J Cardiol. 2006 Jun 15;97 (12) :1697-701., URL: https://pubmed.ncbi.nlm.nih.gov/16765116/, *Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2007 Jan 15;22 (6) :973-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=hartmann+m+blankenstein
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody C7 recognizes human CRP, a 117 kDa acute phase protein; it detects the antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
Applications Notes
ELISA: The antibody C7 has been tested as the detection antibody in a sandwich ELISA for analysis of human C-Reactive Protein in combination with the antibody C5 (cat. no. 11-480-C100) .
Isotype
Mouse IgG1

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