Products for Research Use Only
RegisterLogin

KPB2 rabbit pAb

CAT: 0855-ES15272-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES15272-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010]
Description
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010],
UniProt
P46019
Swiss Prot
P46019
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human KPB2 AA range: 911-961
Target
KPB2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
Gene ID (Human)
5256

UniProtKB · P46019

Phosphorylase b kinase regulatory subunit alpha, liver isoform

KPB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46019
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PHKA2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Phosphorylase kinase alpha L subunit
EC number
—
Processing
—
Secondary accessions
A8K1T1, Q6LAJ5, Q7Z6W0, Q96CR3, Q9UDA1
Protein keywords

Molecular function

Calmodulin-binding

Biological process

Carbohydrate metabolismGlycogen metabolism

Cellular component

Cell membraneMembrane

Disease

Disease variantGlycogen storage disease

PTM

LipoproteinPhosphoproteinPrenylation

Technical term

Proteomics identificationReference proteome

Related Products

CatalogName
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb
ES20658-01NM23A Rabbit rabbit pAb
ES20826-01ATG5 Rabbit rabbit pAb
ES20659-01NBR1 Rabbit rabbit pAb
ES20825-01ATG7 Rabbit rabbit pAb

Alternative Products

CatalogName
E44H15458KPB2 rabbit pAb
BT-AP10877-01KPB2 Rabbit Polyclonal Antibody
GTR18402851-01KPB2 rabbit pAb Antibody
WP16771-01U-Blot® KPB2 rabbit pAb
PAV8491Rabbit Anti-KPB2/PHKA2 Polyclonal Antibody
MBS9520298-01KPB2 Antibody
RTR015Rabbit-to-Rabbit Blocking Reagent
AR05252PU-NRabbit IgG Rabbit Protein
AR05110PU-NRabbit IgM Rabbit Protein
NBP1-71681Rabbit Normal Rabbit Serum

Popular Products