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CES2A-IN-2

CAT: 0804-HY-173267Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173267Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible and covalent CES2A inhibitor with an IC50 of 0.04 nM for human CES2A. CES2A-IN-2 covalently binds to CES2A by specifically targeting the catalytic serine residue (Ser-228). CES2A-IN-2 can significantly ameliorate Irinotecan-triggered gut toxicity (ITGT) without diminishing the anti-tumor effects of Irinotecan in tumor-bearing mice[1].
UNSPSC
12352005
Target
Carboxylesterase (CES)
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Smiles
COC1=C(OC(N(CC)C)=O)C=CC(C(N2CCC(CC3=CC=CC=C3)CC2)=O)=C1
Molecular Formula
C24H30N2O4
Molecular Weight
410.51
References & Citations
[1]Zhipei Sang, et al. AI-Driven Discovery of Highly Specific and Efficacious hCES2A Inhibitors for Ameliorating Irinotecan-Triggered Gut Toxicity. J Med Chem. 2025 Mar 27;68 (6) :6252-6269.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CES1; CES2

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