NIC-0102
CAT:
804-HY-151252-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NIC-0102
- CAS Number: 2806031-94-5
- UNSPSC Description: NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β[1].
- Target Antigen: NOD-like Receptor (NLR); Proteasome
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/nic-0102.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC(C[C@@H](B(O)O)NC([C@@H](NC(C1=C(C=CC=C1F)F)=O)CC2=CC=CC=C2)=O)C
- Molecular Weight: 418.24
- References & Citations: [1]Wu X, et al. Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. J Med Chem. 2022 Sep 5.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported