NT1-014B

• Description :

  NT1-014B is a tryptamine-derived lipidoid. NT1-014B incorporates NT-lipidoid into BBB-impermeable lipid nanoparticles (LNPs), enabling the LNPs to cross the BBB. NT1-014B enhances brain delivery via intravenous injection. NT1-014B can be used in ischemic stroke research[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Biochemical Assay Reagents; Liposome

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/nt1-014b.html

• Concentration :

  10mM

• Purity :

  98.43

• Solubility :

  DMSO : 150 mg/mL (ultrasonic)

• Smiles :

  O=C(CCN(CCC(OCCSSCCCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)OCCSSCCCCCCCCCC

• Molecular Formula :

  C40H68N2O4S4

• Molecular Weight :

  769.24

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020 Jul 24;6 (30) :eabb4429.|[2]Jia Y, et al. Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. Adv Mater. 2025 Mar 27:e2500598.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2739805-64-0]