NT1-O12B

• Description :

  NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB) -impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination[1].

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Liposome

• Type :

  Oligonucleotides

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nt1-o12b.html

• Concentration :

  10mM

• Purity :

  95.0

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCCSSCCOC(CCN(CCC(OCCSSCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)=O

• Molecular Formula :

  C36H60N2O4S4

• Molecular Weight :

  713.13

• References & Citations :

  [1]Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020;6 (30) :eabb4429. Published 2020 Jul 24.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported

• CAS Number :

  [2739805-63-9]