NT1-O12B

CAT: 0804-HY-137499-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137499-01Size:5 mg
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Description
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB) -impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination[1].
CAS Number
[2739805-63-9]
UNSPSC
12352005
Target
Endogenous Metabolite; Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nt1-o12b.html
Concentration
10mM
Purity
95.0
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CCCCCCCCSSCCOC(CCN(CCC(OCCSSCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)=O
Molecular Formula
C36H60N2O4S4
Molecular Weight
713.13
References & Citations
[1]Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020;6 (30) :eabb4429. Published 2020 Jul 24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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