M65 TFA

• Description :

  M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches[1][2].

• UNSPSC :

  12352209

• Target :

  PACAP Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/m65-tfa.html

• Purity :

  99.98

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

• Smiles :

  O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CCC(O)=O)=O)CCCCN)=O)CC4=CC=CC=C4)=O)C(C)C)=O)CO)=O)CC(N)=O)=O)=O)CCC2)=O)C(C)C)=O)CC(N)=O)=O)CO)=O)CC5=CNC=N5)=O)CC6=CNC=N6)=O)C)=O)CCC(N)=O)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CCCCN)=O)CC7=CC=CC=C7)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCC(N)=O)=O)CCCCN)=O)CCSC)=O)=O)CC(O)=O)=O)CC(O)=O)=O)[C@H](CC)C)=O)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CC8=CC=CC=C8)=O)CCC(N)=O)=O)N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)C)=O)CC(O)=O.OC(C(F)(F)F)=O.[x]

• Molecular Formula :

  C205H326N64O61S5.xC2HF3O2

• Molecular Weight :

  4823.53 (free base)

• References & Citations :

  [1]Lerner EA, et al. Maxadilan, a PAC1 receptor agonist from sand flies. Peptides. 2007 Sep;28 (9) :1651-4.|[2]Uchida D, et al. Maxadilan is a specific agonist and its deleted peptide (M65) is a specific antagonist for PACAP type 1 receptor. Ann N Y Acad Sci. 1998 Dec 11;865:253-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported