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IGF-1R modulator 1

CAT: 0804-HY-402309Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-402309Size:1 Each
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Description
IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB) . IGF-1R modulator 1 can be used for research of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease[1].
CAS Number
2375424-89-6
UNSPSC
12352005
Target
EGFR; IGF-1R; Trk Receptor
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/igf-1r-modulator-1.html
Smiles
O=C1NC(N(C(N1C2=CC=CC=C2)=O)C3=CC=C(C(C)=C3)OC4=CC=CC=C4)=O
Molecular Formula
C22H17N3O4
Molecular Weight
387.39
References & Citations
[1]Gunnar Nordvall, et al. Triazine derivatives for treating diseases relating to neurotrophins. Patent. WO2019162702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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