IGF-1R modulator 1

• UNSPSC Description:

  IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB). IGF-1R modulator 1 can be used for research of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease[1].

• Target Antigen:

  EGFR; IGF-1R; Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Neuronal Signaling;Protein Tyrosine Kinase/RTK

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/igf-1r-modulator-1.html

• Smiles:

  O=C1NC(N(C(N1C2=CC=CC=C2)=O)C3=CC=C(C(C)=C3)OC4=CC=CC=C4)=O

• Molecular Weight:

  387.39

• References & Citations:

  [1]Gunnar Nordvall, et al. Triazine derivatives for treating diseases relating to neurotrophins. Patent. WO2019162702.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2375424-89-6