GLP-1R modulator C5

CAT: 0804-HY-141840-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-141840-01Size:5 mg

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Description

GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM) .

CAS Number

421578-93-0

UNSPSC

12352005

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glp-1r-modulator-c5.html

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)CC2(C(N(C3=CC=CC=C32)CCC4=CC=CC=C4)=O)O

Molecular Formula

C24H21NO3

Molecular Weight

371.43

References & Citations

[1]Wang J, et al. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS Chem Biol. 2021 Nov 19;16 (11) :2444-2452.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

GLP-1R modulator C5

CAS Number	421578-93-0
PubChem CID	3967615
IUPAC Name	3-hydroxy-3-phenacyl-1-(2-phenylethyl)indol-2-one
Molecular Formula	C24H21NO3
Molecular Weight	371.4
XLogP	4
Topological Polar Surface Area	57.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Heavy Atom Count	28
Formal Charge	0
Complexity	564

SMILES

C1=CC=C(C=C1)CCN2C3=CC=CC=C3C(C2=O)(CC(=O)C4=CC=CC=C4)O

InChI

InChI=1S/C24H21NO3/c26-22(19-11-5-2-6-12-19)17-24(28)20-13-7-8-14-21(20)25(23(24)27)16-15-18-9-3-1-4-10-18/h1-14,28H,15-17H2

InChIKey

QSAOBVACSHPJMW-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 421578-93-0

CID: 3967615

Formula: C24H21NO3

MW: 371.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	371.4
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	371.15214353
Monoisotopic Mass	371.15214353
Topological Polar Surface Area	57.6 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	564
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T200972-01	GLP-1 Receptor modulator 1
T88615-01	IGF-1R modulator 1
MO15142	GLP-1R
343516-01	GLP-1R discontinued
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GLP-1R modulator C5

Chemical Information

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