IGF-1R inhibitor-3

• UNSPSC Description:

  IGF-1R inhibitor-3 (Compound C11) is an allosteric inhibitor for insulin-like growth factor receptor 1 kinase (IGF-1R), with an IC50 of 0.2 μM[1].

• Target Antigen:

  IGF-1R

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/igf-1r-inhibitor-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(F)=CC2=C1NC=C2C#N)NC3CCN(CCCCC4=CNC5=C4C=C(C#N)C=C5)CC3

• Molecular Weight:

  482.55

• References & Citations:

  [1]Verma J, et al., Structural Models for a Series of Allosteric Inhibitors of IGF1R Kinase. bioRxiv [Preprint]. 2024 May 9:2024.04.04.588115.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1227753-12-9