Rutin (hydrate)

Rutin (hydrate)

• CAS Number: 207671-50-9
• UNSPSC Description: Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress[1][2][3].
• Target Antigen: Amyloid-β; Apoptosis; Autophagy; Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cancer; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Rutin_hydrate.html
• Purity: 98.99
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15.O.[36/5]
• Molecular Weight: 713.04
• References & Citations: [1]Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.|[2]Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.|[3]Xu PX, et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.|[4]Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.Neurotoxicology. 2024 Jul 18:S0161-813X(24)00082-2.|ACS Omega. 2024 Feb 28;9(10):11870-11882.|Adv Sci (Weinh). 2022 Oct 18;e2203088.|Antioxidants (Basel). 2023 Nov 7, 12(11), 1974.|Biology (Basel). 2024 Aug 29.|Food Chem. 16 December 2021, 131872.|Food Chem. 2022: 134807.|Food Res Int. 2024 Oct:193:114812.|iScience. 2023 Sep 6.|Pharmacogn Mag. 2023 Oct 12.|Phytomedicine. 2023 Feb 4;112:154700.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Launched