Rutin

• Description:

  Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress[1][2][3][4][5].

• Product Name Alternative:

  Rutoside; Quercetin 3-O-rutinoside

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Amyloid-β; Apoptosis; Autophagy; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Rutin.html

• Purity:

  98.09

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15

• Molecular Formula:

  C27H30O16

• Molecular Weight:

  610.52

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.|[2]Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23 (9) :860-873.|[3]Xu PX, et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.|[4]Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124 (4) :367-377.|[5]Carlquist M, et al. Flavonoids as inhibitors of human carbonyl reductase 1. Chem Biol Interact. 2008 Jul 30;174 (2) :98-108.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Citation 01:

  Antioxidants (Basel) . 2023 Nov 7;12 (11) :1974.|Biology (Basel) . 2024 Aug 29;13 (9) :676.|Eur J Pharmacol. 2025 Jul 5:998:177536.|Eur Rev Med Pharmacol Sci. 2025 Sep;29 (9) :425-433.|Food Chem. 2022 May 1:375:131872.|Food Chem. 2023 Mar 30;405 (Pt A) :134807.|Food Chem. 2025 Dec 30:497:146992.|Food Chem. 2025 May 31:489:144992.|Food Funct. 2025 Oct 27;16 (21) :8548-8563.|Food Res Int. 2024 Oct:193:114812.|iScience. 2023 Sep 9;26 (10) :107866.|Neuron. 2025 Jul 23;113 (14) :2280-2296.e8.|Pharmacogn Mag. 2023 Oct 12.|Phytomedicine. 2023 Apr:112:154700.|Phytomedicine. 2025 Sep 15:148:157267.|Regulatory Research and Medicine Evaluation. 2025.|SSRN. 2025 Mar 20.|SSRN. 2025 Oct 6.|ACS Omega. 2024 Feb 28;9 (10) :11870-11882.|Adv Sci (Weinh) . 2022 Dec;9 (34) :e2203088.|Arch Endocrinol Metab. 2025 Aug 20;69 (4) :e240410.|Cell Death Differ. 2025 Jun;32 (6) :1041-1057.|Neurotoxicology. 2024 Jul 18:S0161-813X (24) 00082-2.

• CAS Number:

  [153-18-4]