PROTAC AR/AR-V7 degrader-1

PROTAC AR/AR-V7 degrader-1

• CAS Number: 2841308-96-9
• UNSPSC Description: PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1].
• Target Antigen: Adrenergic Receptor; Apoptosis; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;GPCR/G Protein;Neuronal Signaling;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-ar-ar-v7-degrader-1.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O
• Molecular Weight: 485.43
• References & Citations: [1]Maoxu Xiao, et al. Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer. J. Med. Chem. 2024, 67, 7, 5567-5590.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported