Products for Research Use Only
RegisterLogin

Theliatinib

CAT: 0804-HY-104066-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-104066-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases[1]. Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1353644-70-8
Product Name Alternative
Xiliertinib; HMPL-309
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/theliatinib.html
Purity
99.72
Smiles
O=C(N1C[C@]2([H])N(C)CC[C@]2([H])C1)NC3=CC4=C(NC5=CC=CC(C#C)=C5)N=CN=C4C=C3OC
Molecular Formula
C25H26N6O2
Molecular Weight
442.51
References & Citations
[1]Ren Y, et al. Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification. Oncotarget. 2017 Apr 19;8 (31) :50832-50844.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
EGFR/ErbB1/HER1

Alternative Products

CatalogName
BA6357-50Theliatinib
A22215-5Theliatinib 5mg
GTR19212787-01Theliatinib tartrate
A22215-100Theliatinib 100mg
A22215-50Theliatinib 50mg
A22215-10Theliatinib 10mg
A22215-1Theliatinib 1mg
A22215-25Theliatinib 25mg
S8584-01Theliatinib (HMPL-309)

Popular Products