SAMβA (TFA)

• Description :

  SAMβA TFA is conjugated to the cell permeable peptide TAT47-57. SAMβA TFA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA TFA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats[1].

• UNSPSC :

  12352209

• Target :

  PKC

• Type :

  Peptides

• Related Pathways :

  Epigenetics; TGF-beta/Smad

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/samβa-tfa.html

• Purity :

  99.13

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  OC(C(F)(F)F)=O.OC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CC(N)=O)=O)C)=O)CCC(O)=O)=O)CC(N)=O)=O)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O.[x]

• Molecular Formula :

  C50H73N17O16.xC2HF3O2

• Molecular Weight :

  1168.22 (free acid)

• References & Citations :

  [1]Julio C B Ferreira A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019 Jan 18;10 (1) :329.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported