FLT3-IN-27

• UNSPSC Description:

  FLT3-IN-27 (compound 49) is a FLT3-ITD inhibitor with the IC50 of 174 nM. FLT3-IN-27 inhibits cell growth and increases the number of cells in the G1 phase of the cell cycle and can be used for study of acute myeloid leukemia[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-in-27.html

• Smiles:

  O=C(NC1=NN=C(SC2=C3C(OC(C4=CC=CC=C4)=C3)=NC=N2)S1)NC5=CC=C(OC)C=C5

• Molecular Weight:

  476.53

• References & Citations:

  [1]Moradi M, et al. Identification of furo[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazole derivatives as novel FLT3-ITD inhibitors. Eur J Med Chem. 2024 Oct 12;280:116962.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported