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FLT3-IN-34

CAT: 0804-HY-178020Size: 1 EachDry Ice: NoHazardous: No
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Description
FLT3-IN-34 is a FLT3 inhibitor, with an IC50 value of 1.4 nM. FLT3-IN-34 blocks the phosphorylation of FLT3 and its downstream signaling molecules AKT and ERK1/2. FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis in FLT3-ITD-positive MV4-11 cells. FLT3-IN-34 shows potent anti-proliferative activity against FLT3-ITD-positive MV4-11 cells (IC50 = 14.95 nM) and MOLM-13 (IC50 = 18.5 nM) . FLT3-IN-34 can be used for the study of FLT3-positive acute myeloid leukemia (AML) [1].
CAS Number
3020729-11-4
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; FLT3
Related Pathways
Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C(C2=CN=C3C=C(C)C=CN32)=O)C=C1)NC4=NOC(C(C)(C)C)=C4
Molecular Formula
C23H23N5O3
Molecular Weight
417.46
References & Citations
[1]Huang Q, et al. Machine learning-aided design, synthesis and biological evaluation of novel 4- (imidazo[1,2-a]pyridine-3‑carbonyl) phenyl urea derivatives as potent FLT3 inhibitors. Bioorg Chem. 2025 Sep;164:108912.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Flt3-IN-34
CAS Number3020729-11-4
PubChem CID170560017
IUPAC Name1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-(7-methylimidazo[1,2-a]pyridine-3-carbonyl)phenyl]urea
Molecular FormulaC23H23N5O3
Molecular Weight417.5
XLogP4.9
Topological Polar Surface Area102
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity658
SMILES
CC1=CC2=NC=C(N2C=C1)C(=O)C3=CC=C(C=C3)NC(=O)NC4=NOC(=C4)C(C)(C)C
InChI
InChI=1S/C23H23N5O3/c1-14-9-10-28-17(13-24-20(28)11-14)21(29)15-5-7-16(8-6-15)25-22(30)26-19-12-18(31-27-19)23(2,3)4/h5-13H,1-4H3,(H2,25,26,27,30)
InChIKey
SFKSGCKUKLFSPB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flt3-IN-34
CAS: 3020729-11-4
CID: 170560017
Formula: C23H23N5O3
MW: 417.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight417.5
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass417.18008961
Monoisotopic Mass417.18008961
Topological Polar Surface Area102 Ų
Heavy Atom Count31
Formal Charge0
Complexity658
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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