GS-9191

• Description :

  GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection[1].

• Product Name Alternative :

  GCA

• UNSPSC :

  12352005

• Target :

  Apoptosis; DNA/RNA Synthesis; HPV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/gs-9191.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)COC([C@H](CC1=CC=CC=C1)NP(COCCN2C3=NC(N)=NC(NC4CC4)=C3N=C2)(N[C@H](C(OCC(C)C)=O)CC5=CC=CC=C5)=O)=O

• Molecular Formula :

  C37H51N8O6P

• Molecular Weight :

  734.82

• References & Citations :

  [1]Wolfgang GH, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9- (2-phosphonylmethoxyethyl) guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53 (7) :2777-84.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [859209-84-0]