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GS-9191

CAT: 0804-HY-119151-01Size: 1 mgDry Ice: NoHazardous: No
CAT#: HY-119151-01Size: 1 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection[1].
CAS Number
[859209-84-0]
Product Name Alternative
GCA
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; HPV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-9191.html
Solubility
10 mM in DMSO
Smiles
CC(C)COC([C@H](CC1=CC=CC=C1)NP(COCCN2C3=NC(N)=NC(NC4CC4)=C3N=C2)(N[C@H](C(OCC(C)C)=O)CC5=CC=CC=C5)=O)=O
Molecular Formula
C37H51N8O6P
Molecular Weight
734.82
References & Citations
[1]Wolfgang GH, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9- (2-phosphonylmethoxyethyl) guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53 (7) :2777-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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