(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane

• UNSPSC Description:

  (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research[1].

• Target Antigen:

  PDI; Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/racemic-trans-1-2-bis-2-mercaptoacetamido-cyclohexane.html

• Smiles:

  SCC(N[C@H]1[C@@H](CCCC1)NC(CS)=O)=O

• Molecular Weight:

  262.39

• References & Citations:

  [1]Woycechowsky KJ, et al. A small-molecule catalyst of protein folding in vitro and in vivo. Chem Biol. 1999 Dec;6(12):871-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  257641-01-3