1,2-Bis(2-iodoethoxy)ethane

CAT:

804-HY-133143

Size:

1 g

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CAS Number: 36839-55-1
UNSPSC Description: 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Target Antigen: PROTAC Linkers
Type: Reference compound
Related Pathways: PROTAC
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/1-2-bis-2-iodoethoxy-ethane.html
Purity: 98.66
Solubility: 10 mM in DMSO
Smiles: ICCOCCOCCI
Molecular Weight: 369.97
References & Citations: [1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
Shipping Conditions: Room Temperature
Storage Conditions: 4°C (Powder, protect from light)
Clinical Information: No Development Reported

Cat	Name
HY-133143	1,2-Bis(2-iodoethoxy)ethane
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