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Trans-Cyclohexane-1,2-diol

CAT: 0804-HY-W010514-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W010514-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC) . By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells[1][2].
CAS Number
1460-57-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/trans-cyclohexane-1-2-diol.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](O)CCCC1
Molecular Formula
C6H12O2
Molecular Weight
116.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Griesenbach U, et al. Assessment of the nuclear pore dilating agent trans-cyclohexane-1,2-diol in differentiated airway epithelium. J Gene Med. 2012 Jul;14 (7) :491-500.|[2]Pasquet L, et al. Post-pulse addition of trans-cyclohexane-1,2-diol improves electrotransfer mediated gene expression in mammalian cells. Biochem Biophys Rep. 2016 Jul 17;7:287-294.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

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