PERK-IN-6

• UNSPSC Description:

  PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].

• Target Antigen:

  PERK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/perk-in-6.html

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(CC1=NC(C)=CC=C1)N2C3=C(CC2)C=C(C4=CN(C)C5=C4C(N)=NC=N5)C=C3

• Molecular Weight:

  398.46

• References & Citations:

  [1]Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4(10):964-8.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1337532-14-5