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MMAF intermediate 1

CAT: 0804-HY-79253-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-79253-01Size:25 mg
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Description
MMAF intermediate 1 is an intermediate in the synthesis of MMAF (HY-15579) . MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A[1].
CAS Number
[161485-82-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmaf-intermediate-1.html
Purity
99.20
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)OC)OC(C)(C)C
Molecular Formula
C24H36N2O6
Molecular Weight
448.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16 (9) :2562-70. [Content Brief]
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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