MG-V-53

• Description:

  MG-V-53 is a potent small molecule V domain T-cell activating immunoglobulin suppressor (VISTA) inhibitor with IC50 value of 121 nM. MG-V-53 has antitumor activity[1].

• UNSPSC:

  12352005

• Target:

  VISTA

• Type:

  Reference compound

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mg-v-53.html

• Purity:

  90.0

• Smiles:

  FC1C=CC(C2C=CC(OCCNC(CC3C=CC(F)=CC=3)=O)=NN=2)=CC=1

• Molecular Formula:

  C20H17F2N3O2

• Molecular Weight:

  369.37

• References & Citations:

  [1]Abdel-Rahman SA, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints. Sci Adv. 2024 Oct 18;10 (42) :eadq5540.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Dedicated for Diverse Library

• Clinical Information:

  No Development Reported

• CAS Number:

  [920157-23-9]