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HDAC6-IN-53

CAT: 0804-HY-173184Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173184Size:1 Each
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Description
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. HDAC6-IN-53 exerts the activity of inhibiting the phenotype of idiopathic pulmonary fibrosis (IPF) by suppressing the collagen expression induced by TGF-β1, and it has demonstrated a good therapeutic effect in a mouse model of pulmonary fibrosis induced by bleomycin. HDAC6-IN-53 can be used in the research of idiopathic pulmonary fibrosis and other related pulmonary fibrosis diseases.
CAS Number
3081880-03-4
UNSPSC
12352005
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=C(Br)C=C1)NCCC2=CN(CC3=CC=C(C(NO)=O)C=C3)C4=CC=C(OC)C=C42
Molecular Formula
C26H24BrN3O4
Molecular Weight
522.39
References & Citations
[1]Quan J, et al. Discovery of novel selective HDAC6 inhibitors via a scaffold hopping approach for the treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo. Bioorg Chem. 2025 Mar 11;159:108360.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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