STR-V-53

• Description :

  STR-V-53 is an HDAC inhibitor (IC50 in nM) .STR-V-53 increases histone acetylation in tumor cells by inhibiting the activity of these enzymes, which in turn regulates gene expression.STR-V-53 inhibits tumor growth, and induces apoptosis[1].

• UNSPSC :

  12352005

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/str-v-53.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC[C@H]1O[C@H](OC2=CC=C(C3=CN(CCCCCCC(NO)=O)N=N3)C=C2)[C@H](O)[C@@H](O)[C@@H]1O

• Molecular Formula :

  C21H30N4O8

• Molecular Weight :

  466.48

• References & Citations :

  [1]Wu B, et al. A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy. bioRxiv [Preprint]. 2024 Mar 28:2024.03.27.587062.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2798954-66-0]