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STR-V-53

CAT: 0804-HY-161412Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161412Size:1 Each
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Description
STR-V-53 is an HDAC inhibitor (IC50 in nM) .STR-V-53 increases histone acetylation in tumor cells by inhibiting the activity of these enzymes, which in turn regulates gene expression.STR-V-53 inhibits tumor growth, and induces apoptosis[1].
CAS Number
2798954-66-0
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/str-v-53.html
Solubility
10 mM in DMSO
Smiles
OC[C@H]1O[C@H](OC2=CC=C(C3=CN(CCCCCCC(NO)=O)N=N3)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
Molecular Formula
C21H30N4O8
Molecular Weight
466.48
References & Citations
[1]Wu B, et al. A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy. bioRxiv [Preprint]. 2024 Mar 28:2024.03.27.587062.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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