STR-V-53

• UNSPSC Description:

  STR-V-53 is an HDAC inhibitor (IC50 in nM).STR-V-53 increases histone acetylation in tumor cells by inhibiting the activity of these enzymes, which in turn regulates gene expression.STR-V-53 inhibits tumor growth, and induces apoptosis[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/str-v-53.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@H]1O[C@H](OC2=CC=C(C3=CN(CCCCCCC(NO)=O)N=N3)C=C2)[C@H](O)[C@@H](O)[C@@H]1O

• Molecular Weight:

  466.48

• References & Citations:

  [1]Wu B, et al. A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy. bioRxiv [Preprint]. 2024 Mar 28:2024.03.27.587062.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2798954-66-0