PROTAC 20S proteasome subunit β5 degrader 2

• UNSPSC Description:

  PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC50 of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC50 of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models[1]. (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

• Target Antigen:

  PROTACs; Proteasome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-20s-proteasome-subunit-β5-degrader-2.html

• Smiles:

  O=C1CCC(C(N1)=O)N2C(C3=C(C(OCC(NC4=CC=C(C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](B6O[C@@]7(C)[C@@H](C[C@H]8CC7O6)C8(C)C)CC(C)C)=O)=O)=O)=CC=C3)C2=O)=O

• Molecular Weight:

  845.74

• References & Citations:

  [1]Wang S, et al., Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma. Bioorg Chem. 2024 Sep 3;153:107801.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported