2-Bromo-4'-hydroxyacetophenone

• Description:

  2-Bromo-4'-hydroxyacetophenone is a PTP1B inhibitor with a Ki value of 42 μM. 2-Bromo-4'-hydroxyacetophenone is also an intermediate. 2-Bromo-4'-hydroxyacetophenone can be used in the synthesis of LXRα/β antagonists. 2-Bromo-4'-hydroxyacetophenone can be used in research on hematological diseases[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H319

• Target:

  Drug Intermediate; Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-bromo-4-hydroxyacetophenone.html

• Purity:

  98.59

• Solubility:

  DMSO : 200 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(C(CBr)=O)C=C1

• Molecular Formula:

  C8H7BrO2

• Molecular Weight:

  215.05

• Precautions:

  H302, H319

• References & Citations:

  [1]Sidhu, Alban, et al. Toward Inhibitors of Protein Tyrosine Phosphatases for Cancer Treatment. Home / Current Enzyme Inhibition, Volume 4, Number 1.|[2]Nian S, et al. Discovery and Synthesis of a Novel Series of Liver X Receptor Antagonists. Chem Pharm Bull (Tokyo) . 2015;63 (8) :628-35.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2491-38-5]