YTHDC1 antibody

CAT: 0710-FNab09571Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab09571Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552) . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552) . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937) . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937) . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937) . May also regulate alternative splice site selection (PubMed:20167602) .
Synonyms
YTH domain-containing protein 1|Splicing factor YT521 (YT521-B) |YTHDC1|KIAA1966|YT521
Gene ID
91746
UniProt
Q96MU7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
YTH domain containing 1
Target
YTHDC1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

Related Products

CatalogName
P2220-01Recombinant Human YTHDC1
EH13705Human YTHDC1 (YTH domain-containing protein 1) ELISA Kit
QT-EH13705Human YTHDC1 (YTH domain-containing protein 1) QuickTest ELISA Kit
FNab10487YTHDC2 antibody
FNab09572YTHDF1 antibody
FNab09574YTHDF3 antibody
FNab09573YTHDF2 antibody
P1101-01Recombinant Human YTHDF1
Pr3647-01Recombinant Human YTHDF3
P1982-01Recombinant Human YTHDF2

Alternative Products

CatalogName
MBS7050984-01YTHDC1 Antibody
MBS1753726-01Anti-YTHDC1 Antibody
BS70787-01YTHDC1 polyclonal antibody
CST 54737SYTHDC1 (D10) Antibody
CST 87459SYTHDC1 (P561) Antibody
TA337926YTHDC1 Rabbit Polyclonal Antibody
MBS8564025-01YTHDC1

Popular Products