YTHDC1 polyclonal antibody

CAT: 0384-BS70787-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS70787-01Size:50 µL
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Background
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
YTHDC1; YT521; YT521-B
Swiss Prot
Q96MU7
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human YTHDC1 (NP_001026902.1) .
Conjugation
Unconjugated
Applications
WB
Dilution
WB,1:1000 - 1:5000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
110KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
YTHDC1 polyclonal antibody detects endogenous levels of YTHDC1 protein.
Applications Notes
Western blot analysis of various lysates using YTHDC1 pAb at 1:2000 dilution.
Host or Source
Rabbit

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