USP20 antibody

CAT: 0710-FNab09317Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab09317Size:100 µg
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Background
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) . Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
Synonyms
Ubiquitin carboxyl-terminal hydrolase 20|Deubiquitinating enzyme 20|Ubiquitin thioesterase 20|Ubiquitin-specific-processing protease 20|VHL-interacting deubiquitinating enzyme 2 (hVDU2) |USP20|KIAA1003|LSFR3A|VDU2
Gene ID
10868
UniProt
Q9Y2K6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ubiquitin specific peptidase 20
Target
USP20
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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