USP13 antibody

CAT: 0710-FNab09309Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab09309Size:100 µg
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Background
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD) . Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD) . Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Synonyms
Ubiquitin carboxyl-terminal hydrolase 13|Deubiquitinating enzyme 13|Isopeptidase T-3 (ISOT-3) |Ubiquitin thioesterase 13|Ubiquitin-specific-processing protease 13|USP13|ISOT3
Gene ID
8975
UniProt
Q92995
Host
Mouse
Reactivity
Human
Immunogen
Ubiquitin specific peptidase 13 (isopeptidase T-3)
Target
USP13
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
97 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9E6
Tested Applications
ELISA, WB, IHC, IF

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