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TRAF3 antibody

CAT: 0710-FNab08917Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08917Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
Synonyms
TNF receptor-associated factor 3|CD40 receptor-associated factor 1 (CRAF1) |CD40-binding protein (CD40BP) |LMP1-associated protein 1 (LAP1) |RING-type E3 ubiquitin transferase TRAF3|TRAF3|CAP-1|CRAF1|TRAFAMN
Gene ID
7187
UniProt
Q13114
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TNF receptor-associated factor 3
Target
TRAF3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200 - 1:1000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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