TCHP antibody

• Background:

  Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701) . Is a negative regulator of ciliogenesis (PubMed:25270598) .

• Synonyms:

  Trichoplein keratin filament-binding protein (Protein TCHP) |Mitochondrial protein with oncostatic activity (Mitostatin) |Tumor suppressor protein|TCHP

• Gene ID:

  84260

• UniProt:

  Q9BT92

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Trichoplein, keratin filament binding

• Target:

  TCHP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Cancer

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  61 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB