CA15-3 antibody (detection antibody)

• Background:

  The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

• Synonyms:

  Mucin-1 (MUC-1) |Breast carcinoma-associated antigen DF3|Cancer antigen 15-3 (CA 15-3) |Carcinoma-associated mucin|Episialin|H23AG|Krebs von den Lungen-6 (KL-6) |PEMT|Peanut-reactive urinary mucin (PUM) |Polymorphic epithelial mucin (PEM) |Tumor-associated epithelial membrane antigen (EMA) |Tumor-associated mucin|Mucin-1 subunit alpha (MUC1-NT, MUC1-alpha) |Mucin-1 subunit beta (MUC1-beta) Alternative names: MUC1-CT|MUC1|PUM

• Gene ID:

  4582

• UniProt:

  P15941

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Mucin 1, cell surface associated

• Target:

  CA15-3

• Clonality:

  Monoclonal

• Isotype:

  IgG2b

• Purification:

  Protein A+G purified

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.1% Proclin300, pH 7.4, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  8H2

• Tested Applications:

  ELISA, CLIA, GICA