SMARCA4 antibody

SMARCA4 antibody

• Background: SMARCA4, also named as BAF190A, BRG1, SNF2B and SNF2L4, belongs to the SNF2/RAD54 helicase family. SMARCA4 is a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It is a component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. It is also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor(VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
• Synonyms: Transcription activator BRG1|ATP-dependent helicase SMARCA4|BRG1-associated factor 190A (BAF190A)|Mitotic growth and transcription activator|Protein BRG-1|Protein brahma homolog 1|SNF2-beta|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4|SMARCA4|BAF190A|BRG1|SNF2B|SNF2L4
• CAS Number: 9007-83-4
• Gene ID: 6597
• UniProt: P51532
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
• Target: SMARCA4
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IHC, IF, IP
• Field of Research: Epigenetics, Stem Cells, Metabolism
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:2000; IP:1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 185 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)