SMARCD1 antibody

CAT: 0710-FNab08010Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08010Size:100 µg
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Background
Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) . During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF) . The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity) . Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE) . May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.
Synonyms
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1|60 kDa BRG-1/Brm-associated factor subunit A|BRG1-associated factor 60A (BAF60A) |SWI/SNF complex 60 kDa subunit|SMARCD1|BAF60A
Gene ID
6602
UniProt
Q96GM5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Target
SMARCD1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
58 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

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