SMARCA4 antibody

• Background :

  The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

• Synonyms :

  Transcription activator BRG1|ATP-dependent helicase SMARCA4|BRG1-associated factor 190A (BAF190A) |Mitotic growth and transcription activator|Protein BRG-1|Protein brahma homolog 1|SNF2-beta|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4|SMARCA4|BAF190A|BRG1|SNF2B|SNF2L4

• Gene ID :

  6597

• UniProt :

  P51532

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

• Target :

  SMARCA4

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IF

• Field of Research :

  Epigenetics, Stem Cells, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:20 - 1:50

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  180 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IF

• Immunogen Sequence :

  30-130aa