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PTPN11 antibody

CAT: 0710-FNab07854Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07854Size:100 µg
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Background
PTPN11 (protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism (PMID:19017799) . Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions (PMID:21576358) . Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC) . It has 3 isoforms produced by alternative splicing.
Synonyms
Tyrosine-protein phosphatase non-receptor type 11|Protein-tyrosine phosphatase 1D (PTP-1D) |Protein-tyrosine phosphatase 2C (PTP-2C) |SH-PTP2 (SHP-2, Shp2) |SH-PTP3|PTPN11|PTP2C|SHPTP2
UniProt
Q06124
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein tyrosine phosphatase, non-receptor type 11
Target
PTPN11
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
68 kDa, 53 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

UniProtKB · Q06124

Tyrosine-protein phosphatase non-receptor type 11

PTN11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q06124
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPN11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
—
Secondary accessions
A8K1D9, Q96HD7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

DeafnessDisease variant

Molecular function

HydrolaseProtein phosphatase

Domain

RepeatSH2 domain

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CatalogName
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