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PTPN22 antibody

CAT: 0710-FNab06936Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06936Size:100 µg
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Background
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643) . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704) . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343) . Dephosphorylates the immune system activator SKAP2 (PubMed:21719704) . Positively regulates toll-like receptor (TLR) -induced type 1 interferon production (PubMed:23871208) . Promotes host antiviral responses mediated by type 1 interferon (By similarity) . Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106) .
Synonyms
Tyrosine-protein phosphatase non-receptor type 22|Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP|Lymphoid phosphatase (LyP) |PEST-domain phosphatase (PEP) |PTPN22|PTPN8
Gene ID
26191
UniProt
Q9Y2R2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Target
PTPN22
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
79-95 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

UniProtKB · Q9Y2R2

Tyrosine-protein phosphatase non-receptor type 22

PTN22_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y2R2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPN22
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
—
Secondary accessions
A0N0K6, B1ALC8, D4NZ71, E9PLD8, E9PPI1, O95063, O95064, Q6IPX8, Q8WVM1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AutophagyImmunityLipid metabolism

Cellular component

Cytoplasm

Disease

Diabetes mellitusDisease variantSystemic lupus erythematosus

PTM

Disulfide bondPhosphoprotein

Molecular function

HydrolaseProtein phosphatase

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