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CRADD antibody

CAT: 0710-FNab07092Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07092Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RAIDD, also named as CRADD, is an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1. It is a negative regulator of the CARMA1 signalosome and suppressor of Th1-and Th17-mediated inflammatory responses.
Synonyms
Death domain-containing protein CRADD|Caspase and RIP adapter with death domain|RIP-associated protein with a death domain|CRADD|RAIDD
UniProt
P78560
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CASP2 and RIPK1 domain containing adaptor with death domain
Target
CRADD
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
23 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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